I am heading the joint Inria/ICM Aramis Lab with O. Colliot at the Brain and Spine Institute (ICM) located within the Pitié-Salpêtrière hospital in Paris. I am also the coordinator of the ICM Center of Neuroinformatics, and scientific director of the ICM platform of biostatistics and bioinformatics. My team focuses on the development of new statistical and computational approaches for the analysis of image data and image-derived geometric data such a surface meshes. We have contributed to the definition of statistical analysis methods for spatiotemporal measurements in longitudinal studies, where sets of geometric objects (or structured data) are observed at multiple points in time. Our research is essentially motivated by, and applied to the study of the structure and function of the human brain. It makes accessible the wealth and complexity of information contained in multiple modalities of medical images via virtual representations of the brain, and allows the tracking of these representations during ageing or disease progression.